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C3GA rare kidney disease caused by an overactive complement system, a part of your immune system that normally helps fight infections. In C3G, the complement system mistakenly attacks the kidneys, causing C3 fragments to build up. Over time, this buildup leads to inflammation and kidney damage.C3G (C3 glomerulopathy) and Primary IC-MPGN A rare kidney disease caused by an overactive complement system, a part of your immune system that normally helps fight infections. In primary IC-MPGN, the complement system mistakenly attacks the kidneys, causing immunoglobulin fragments (antibody proteins) or a combination of immunoglobulin and C3 fragments to build up. Over time, this buildup leads to inflammation and kidney damage.primary IC-MPGN (immune-complex membranoproliferative glomerulonephritis) are rare kidney diseases that can add challenges to the lives of children and adults. C3G and primary IC-MPGN are often misunderstood because they can look different from person to person. However, awareness and research are growing.

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