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C3GA rare kidney disease caused by an overactive complement system, a part of your immune system that normally helps fight infections. In C3G, the complement system mistakenly attacks the kidneys, causing C3 fragments to build up. Over time, this buildup leads to inflammation and kidney damage.C3G (C3 glomerulopathy) and Primary IC-MPGN A rare kidney disease caused by an overactive complement system, a part of your immune system that normally helps fight infections. In primary IC-MPGN, the complement system mistakenly attacks the kidneys, causing immunoglobulin fragments (antibody proteins) or a combination of immunoglobulin and C3 fragments to build up. Over time, this buildup leads to inflammation and kidney damage.primary IC-MPGN (immune-complex membranoproliferative glomerulonephritis) are rare kidney diseases that can affect children and adults.

Living with a rare disease can feel confusing and overwhelming. We’re here to help you better understand your journey, explore support options, and feel more confident moving forward.

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